VERZWEIGTE ALKYLESTER VON 4-BIS(CHLOROALKYL)AMINOPHENYLALKYLCARBONSAEURE

Tertiary butyl esters for use an anticancer drugs have the formula: wherein R1 and R2 are the same or are different and each is H, Cl, F, Br or I, and R2 may also be NH2; R3, R4 and R5 are the same or are different and each is H, F, Cl, Br or I or C1-C3 alkyl which may be substituted with F, Cl, Br,...

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Bibliographische Detailangaben
Hauptverfasser:	GREIG, NIGEL H., WASHINGTON, D.C. 20007, US, RAPOPORT, STANLEY I., WASHINGTON D. C. 20016, US, SWEENEY, DANIEL J., INDIANAPOLIS, INDIANA 46219, US
Format:	Patent
Sprache:	ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Tertiary butyl esters for use an anticancer drugs have the formula: wherein R1 and R2 are the same or are different and each is H, Cl, F, Br or I, and R2 may also be NH2; R3, R4 and R5 are the same or are different and each is H, F, Cl, Br or I or C1-C3 alkyl which may be substituted with F, Cl, Br, or I; with the proviso that at least two of R3, R4, and R5 are alkyl or substituted alkyl; and n is an integer of 0-4. The compounds can be used in treating cancer by significantly increasing the brain levels of the drugs of the invention and their active metabolites.