Verfahren zur Herstellung von Hylan und Hylanverbindungen

Disclosed is hylan, a chemically modified hyaluronan preparation characterized by the presence of small amounts (0.0002-0.05% by weight) of aldehyde cross-linking groups covalently bonded to the hyaluronan molecular chains. Also disclosed is an improved method of obtaining hylan comprising treating...

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Bibliographische Detailangaben
Hauptverfasser:	LESHCHINER, ADELYA, FAIRVIEW, NJ 07022, US, BAND, PHILIP, BROOKLYN NEW YORK, US, BALAZS, ENDRE A., FORT LEE, NJ 07024, US, LARSEN, NANCY E., SOUTHFIELD NY 10975, US, LESHCHINER, ADOLF, FAIRVIEW, NJ 07022, US
Format:	Patent
Sprache:	ger
Schlagworte:	CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS THEIR PREPARATION OR CHEMICAL WORKING-UP
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Beschreibung
Zusammenfassung:	Disclosed is hylan, a chemically modified hyaluronan preparation characterized by the presence of small amounts (0.0002-0.05% by weight) of aldehyde cross-linking groups covalently bonded to the hyaluronan molecular chains. Also disclosed is an improved method of obtaining hylan comprising treating hyaluronan in situ in animal tissues containing same with a treatment mixture including an aldehyde which is reactive towards hyaluronic acid and the proteins contained in the animal tissue. Treatment is effected at temperatures below about 16 DEG C at very high pH, e.g. 8-14 whereby the overall yield is increased while maintaining the high molecular weight of the hylan.