Galenische Formen von antiinflammatorischen Gammaglobulinen für die sublinguale Verabreichung

These new pharmaceutical dosage forms are characterised in that the gamma-globulins are present in strictly controlled and reproducible amounts in solid vehicles contrived for a gradual release of the active principle on per- and sublingual administration. The process for preparing these dosage form...

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Bibliographische Detailangaben
Hauptverfasser: PEDRALI, PATRICK, F-74000 ANNECY LE VIEUX, FR, BRUTTMANN, GEORGES, F-38000 GRENOBLE, FR, ROBERT, SERGE, BRAINE LE CHATEAU, BE
Format: Patent
Sprache:ger
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Beschreibung
Zusammenfassung:These new pharmaceutical dosage forms are characterised in that the gamma-globulins are present in strictly controlled and reproducible amounts in solid vehicles contrived for a gradual release of the active principle on per- and sublingual administration. The process for preparing these dosage forms comprises the following steps: - obtaining a solution of inflammatory gamma-globulins in the form of a rabbit anti-HLA serum or plasma solution; - preparation of dilutions of this solution using a suitable solvent; - impregnation by multi-impregnation or fractional impregnation of a pharmaceutically acceptable solid vehicle with each of the dilutions, each of these impregnation steps being followed by forced-air drying with moisture-free air at a temperature not exceeding 30 DEG C; - protective final impregnation of the sugar-coating type.