IMPFSTOFF GEGEN VARICELLA-ZOSTER-VIRUS

A gene of varicella-zoster virus (VZV) which encodes immunogenic outer surface viral proteins has been identified by DNA sequence analysis. This gene can hybrid select messenger RNA which encodes and expresses a protein which reacts with human convalescent zoster sera and with polyclonal monospecifi...

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Hauptverfasser: DAVISON, ANDREW J., GLASGOW SCOTLAND, GB, ELLIS, RONALD W., OVERBROOK HILLSPENNSYLVANIA 19151, US, LOWE, ROBERT S., HARLEYSVILLE PENNSYLVANIA 19438, US, KELLER, PAUL M., LANSDALE PENNSYLVANIA 19446, US
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Sprache:ger
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Zusammenfassung:A gene of varicella-zoster virus (VZV) which encodes immunogenic outer surface viral proteins has been identified by DNA sequence analysis. This gene can hybrid select messenger RNA which encodes and expresses a protein which reacts with human convalescent zoster sera and with polyclonal monospecific antisera which neutralize viral infectivity. These proteins are useful for the preparation of a vaccine for VZV.