Antigene Proteine und diese enthaltende Impfstoffe zur Verhütung von Kokzidiose

Isolated genomic DNA molecule having a defined nucleic acid sequence and encoding an antigenic protein (I) derived from Eimeria tenella is new. (I) has a molecular wt. of about 25000 daltons and is composed of two polypeptides joined by a disulphide bond. One polypeptide has a molecular wt. of about...

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Hauptverfasser: GORE, THOMAS C., CHARLES CITY, IA 50616, US, SIAS, STACEY R., SAN ANSELMO, CA 94960, US, NEWMAN, KAREL Z., JR., CLEAR LAKE, IA 50428, US, KUHN, IRENE, SAN FRANCISCO, CA 94117, US, ANDREWS, WILLIAM H., BELMONT, CA 94002, US, PETERSEN, GARY R., CHARLES CITY, IA 50616, US, BROTHERS, VIRIGINIA M., ALBANY, CA 94706, US, CHANG, RAY-JEN, FOSTER CITY, CA 94404, US, NORDGREN, ROBERT M., CHARLES CITY, IA 50616, US, TEDESCO, JOHN L., ST. PETERS, MO 63376, US, FILES, JAMES G., BELMONT, CA 94002, US, PAUL, LELAND S., ISLAND LAKE, IL 60042, US, MCCAMAN, MICHAEL, SAN BRUNO, CA 94066, US, DRAGON, ELIZABETH B., ORINDA, CA 94563, US
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Zusammenfassung:Isolated genomic DNA molecule having a defined nucleic acid sequence and encoding an antigenic protein (I) derived from Eimeria tenella is new. (I) has a molecular wt. of about 25000 daltons and is composed of two polypeptides joined by a disulphide bond. One polypeptide has a molecular wt. of about 17000 daltons, has a blocked N-terminal amino acid and a defined amino acid sequence. The other polypeptide has a molecular wt. of about 8000 daltons and a defined amino acid sequence.