Substituted 1,4-dihydropyridine-3-carboxylic acid derivatives

Substituted 1,4-dihydropyridine-3-carboxylic acid derivatives of the general formula I in which Ar represents a cycle of the formula in which Y denotes oxygen (O), sulphur (S), vinylene (-CH=CH-), azomethine (-CH=N-) or a group of the formula R1, R2 and R3 are identical or different and denote hydro...

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Hauptverfasser: RUEDIGER,WOLF-ULRICH,DR, ELTZE,MANFRID,DR, KOLASSA,NORBERT,DR, AMSCHLER,HERMANN,DR, SCHUDT,CHRISTIAN,DR, EISTETTER,KLAUS,DR, FLOCKERZI,DIETER,DR, KLEMM,KURT,DR, SANDERS,KARL,DR
Format: Patent
Sprache:eng ; ger
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Zusammenfassung:Substituted 1,4-dihydropyridine-3-carboxylic acid derivatives of the general formula I in which Ar represents a cycle of the formula in which Y denotes oxygen (O), sulphur (S), vinylene (-CH=CH-), azomethine (-CH=N-) or a group of the formula R1, R2 and R3 are identical or different and denote hydrogen, C1-C6-alkyl, C3-C7-alkoxyalkyl, aryl, aryl-C1-C6-alkyl or aryloxy-C1-C6-alkyl, R4 and R5 are identical or different and denote hydrogen, hydroxyl, halogen, nitro, cyano, trifluoromethyl, C1-C4-alkyl, C1-C4-alkoxy, completely or partially fluorine-substituted C1-C4-alkoxy, C1-C4alkoxy-carbonyl, C2-C5-acyl, amino or mono- or di-C1-C4-alkylamino, R6, R7, R8 and R9 are identical or different and denote hydrogen, hydroxyl, halogen, C1-C4-alkyl, C1-C4-alkoxy, amino, mono- or di-C1-C4-alkylamino or completely or partially fluorine-substituted C1-C4-alkoxy, A denotes straight-chain or branched C2-C5-alkylene which can be substituted by C1-C4-alkoxy or aryl, and their salts are novel compounds for the treatment and prophylaxis of circulation-related diseases.