Slow release tablets prepn. by wet granulation

Slow release tablets prepn. by wet granulation

A pharmaceutical prepn., esp. a tablet, contains (A) as known (a) not more than 800 mg/g active ingredient, (b) a vinylpyrrolidone/vinyl acetate copolymer and (c) pref. 0.5-10 wt.%, fatty substance, pref. cetyl stearyl alcohol, (B) at least 10 wt.% acrylic acid polymer crosslinked by polyalkyl-sacch...

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Bibliographische Detailangaben
Hauptverfasser: FEKETE, PAL., BUDAPEST, HU, TOTH, ZOLTAN., BUDAPEST, HU, FELLNER, GEB. KOEHALMI, ERZSEBET, BUDAPEST, HU, BOR, GEB. BAUMGARTNER, ILONA, BUDAPEST, HU, BEZZEGH, DENES, BUDAPEST, HU
Format: Patent
Sprache:eng ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:A pharmaceutical prepn., esp. a tablet, contains (A) as known (a) not more than 800 mg/g active ingredient, (b) a vinylpyrrolidone/vinyl acetate copolymer and (c) pref. 0.5-10 wt.%, fatty substance, pref. cetyl stearyl alcohol, (B) at least 10 wt.% acrylic acid polymer crosslinked by polyalkyl-saccharose, pref. also (C) polyoxyethylene, polyvinylpyrrolidone and/or OH-alkyl(alkyl)cellulose and (D) an inert support, and/or fillers and/or aids, esp. tabletting aids. (Ab) pref. contains 60 wt.% vinylpyrrolidone units and 40 wt.% vinyl acetate units. The wt. ratio (C):((B)+Ab)) is 0.5-100 to 1:1. The active ingredient is e.g. chloro-pyramin, nitroglycerin.