Alpha amylase inactivators for Streptomyces tendae - useful for lowering blood sugar levels

The alpha-amylase inactivators HOE 467-A and HOE 467-B, and their mixts. are new. The amino acid compsn. of HOE 467-A is Asp 6; Thr 8; Ser 5; Glu 7; Pro 3; Gly 7; Ala 7; Val 8; Cys 4; Ile 2; Leu 4; Tyr 6; His 2; Lys 1; Arg 3; Tp 1, and its isoelectric point is 4.38-4.68. The inactivators are prepd....

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Bibliographische Detailangaben
Hauptverfasser:	MRACEK,MIROSLAV,-BIOL, VERTESY,LASZLO,.DR
Format:	Patent
Sprache:	eng ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The alpha-amylase inactivators HOE 467-A and HOE 467-B, and their mixts. are new. The amino acid compsn. of HOE 467-A is Asp 6; Thr 8; Ser 5; Glu 7; Pro 3; Gly 7; Ala 7; Val 8; Cys 4; Ile 2; Leu 4; Tyr 6; His 2; Lys 1; Arg 3; Tp 1, and its isoelectric point is 4.38-4.68. The inactivators are prepd. by cultivating Streptomyces tendae ATCC 31210 or HAG 1266 (the second claimed as a new organism) and recovery by adsorption on resins or by reverse-phase chromatography. The inactivators are used to regulate the level of sugars in the blood, esp. for treating diabetes, pre-diabetic states or adiposity. They are resistant to enzymatic degradation; produced no toxic signs in mice when given at 1 g per kg (intraveneously) and are pref. administered at doses of 10000-300000 amylose-inhibiting units.