VERFAHREN ZUR HERSTELLUNG VON BROMHEXIN

VERFAHREN ZUR HERSTELLUNG VON BROMHEXIN

N-(2-amino-3,5-dibromobenzyl)- N-methyl-cyclohexylamine, the hydrochloride of which has the formula is prepared by brominating 1,4- dihydro-2H-3,1-benzoxazin-2-one with free bromine to form the hitherto unknown intermediate 6,8-dibromo- 1,4-dihydro-2H-3,1-benzoxazin-2- one, and reacting this with N-...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ALHEDE,BORGE, GELTING,NIELS, PREIKSCHAT,HERBERT
Format: Patent
Sprache:ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:N-(2-amino-3,5-dibromobenzyl)- N-methyl-cyclohexylamine, the hydrochloride of which has the formula is prepared by brominating 1,4- dihydro-2H-3,1-benzoxazin-2-one with free bromine to form the hitherto unknown intermediate 6,8-dibromo- 1,4-dihydro-2H-3,1-benzoxazin-2- one, and reacting this with N-methyl- cyclohexylamine to bromhexin. Preferably, the reaction takes place by heating in N-monomethylformamide to the boiling point of the latter.