NEUE L-(ACYLAMINO-ARYLOXY-)2-HYDROXY-3-ALKINYLAMINOPROPANE UND VERFAHREN ZU IHRER HERSTELLUNG

This invention relates to a compound of the formula (I) wherein R1 is ethyl or isopropyl; R2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or a bivalent radical -CH=CH-CH=CH- or -(CH2)n-, where n is an integer from 3 to 5, inclusive, and the free bonds of said biv...

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Hauptverfasser: KOEPPE,HERBERT,DR, MUACEVIC,GOJKO,DR, STAEHLE,HELMUT,DR, TRAUNECKER,WERNER,DR, KUMMER,WERNER,DR
Format: Patent
Sprache:ger
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Zusammenfassung:This invention relates to a compound of the formula (I) wherein R1 is ethyl or isopropyl; R2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or a bivalent radical -CH=CH-CH=CH- or -(CH2)n-, where n is an integer from 3 to 5, inclusive, and the free bonds of said bivalent radical are attached to adjacent carbon atoms of the phenyl ring; and R3 is hydrogen or alkyl of 1 to 3 carbon atoms; R4 is alkyl of 1 to 3 carbon atoms; or R3 and R4, together with each other, are -(CH2)p-, where p is an integer from 4 to 6, inclusive, or a non-toxic, pharmacologically acceptable acid addition salt thereof. The compounds of formula I are useful for treatment and prophylaxis of diseases of the coronaries, for treatment of hypertension, and for treatment of cardiac arrhythmia, particularly tachycardia.