VERFAHREN ZUR HERSTELLUNG VON 1 ALPHA, 3 BETA -DIHYDROXY- DELTA HOCH 5 -STEROIDEN

A process for the synthesis of 1 alpha ,3 beta -dihydroxy- DELTA 5-steroids from steroids such as 1 alpha ,2 alpha -epoxy-cholesta-4,6-dien-3-one, which is reacted with lithium in liquid ammonia in the absence of a proton donator and subsequently reduced by repeated alternative additions of a proton...

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Hauptverfasser: LABLER,LUDWIG,DR, MEIER,WERNER,DR, FUERST,ANDOR,DR
Format: Patent
Sprache:ger
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Zusammenfassung:A process for the synthesis of 1 alpha ,3 beta -dihydroxy- DELTA 5-steroids from steroids such as 1 alpha ,2 alpha -epoxy-cholesta-4,6-dien-3-one, which is reacted with lithium in liquid ammonia in the absence of a proton donator and subsequently reduced by repeated alternative additions of a proton donator, said additions being followed in each case by an equivalent amount of lithium. The final product, a 1 alpha ,3 beta -dihydorxy- DELTA 5-steroid, is useful in the synthesis of derivatives of cholecalciferol.