VERFAHREN ZUR HERSTELLUNG VON CEPHALOSPORINVERBINDUNGEN

VERFAHREN ZUR HERSTELLUNG VON CEPHALOSPORINVERBINDUNGEN

A process for the preparation of cephalosporins having a phosphonocarbamoyloxymethyl group at the 3-position by reacting a cephalosporin having at the 3-position a group (wherein R4 and R5 are independently alkyl, aralkyl, alicyclic or aryl groups or together form a divalent group) with a compound o...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: GAD WEINGARTEN,GORDON, BRUCE LAING,STUART
Format: Patent
Sprache:ger
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A process for the preparation of cephalosporins having a phosphonocarbamoyloxymethyl group at the 3-position by reacting a cephalosporin having at the 3-position a group (wherein R4 and R5 are independently alkyl, aralkyl, alicyclic or aryl groups or together form a divalent group) with a compound of formula (wherein R6, R7 and R8 are independently alkyl, aralkyl, alicyclic or aryl groups or any two of R6, R7 and R8 together form a divalent group, and X is halogen) followed by hydrolysis. The 3-phosphonocarbamoyloxymethyl cephalosporin products of the process exhibit antibiotic activity, and if desired may be readily converted to 3-carbamoyloxymethyl cephalosporins which themselves show antibiotic activity.