Benzo:dioxanyl-hydroxyethyl-piperidyl-imidazolidone derivs. - having hypotensive activity, and prepd. by reacting a piperidin-4-yl-imidazolidinone with a halo-hydroxyethyl-benzodioxan

Benzo:dioxanyl-hydroxyethyl-piperidyl-imidazolidone derivs. - having hypotensive activity, and prepd. by reacting a piperidin-4-yl-imidazolidinone with a halo-hydroxyethyl-benzodioxan

New benzodioxanyl-hydroxyethyl-piperidyl-imidazolidinone derivs. are cpds. of formula (I) and their acid addn. salts. In (I) R is H, 1-5C alkyl, opt. substd. phenyl or a gp. -CO-R1 in which R1 is 1-4C alkyl or phenyl. (I) are prepd. by reaction of (II) and (III). In the formula Z is -CH-CH2O or -CHO...

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Hauptverfasser: LANGBEIN,ADOLF,DR, WALTHER,GERHARD,DR, GAIDA,WOLFRAM,DR, HOEFKE,WOLFGANG,DR
Format: Patent
Sprache:eng ; ger
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:New benzodioxanyl-hydroxyethyl-piperidyl-imidazolidinone derivs. are cpds. of formula (I) and their acid addn. salts. In (I) R is H, 1-5C alkyl, opt. substd. phenyl or a gp. -CO-R1 in which R1 is 1-4C alkyl or phenyl. (I) are prepd. by reaction of (II) and (III). In the formula Z is -CH-CH2O or -CHOH-CH2Y in which Y is Cl, Br, I, arylsulphonyloxy or alkylsulphonyloxy. The reaction is pref. carried out in the presence of an acid binding agent in an inert organic solvent. (I) have marked and long-lasting hypotensive activity, and are active after oral admin. The alpha-adrenolytic activity of (I) is less than that of structurally similar known cpds., but the hypotensive effect of (I) is accompanied by an advantageous lowering of heart rate. dosage is 0.5-10 (pref. 1-5) mg orally.