DE2834167

Prodn. of 2-(2-hydroxyethoxy)ethyl N-(alpha, alpha, alpha-trifluoro-m-tolyl)anthranilate (I) comprises reacting N-(alpha, alpha, alpha-trifluoro-m-tolyl)anthranilic acid (II) with diethylene glycol (III) in presence of acid catalyst, and opt. of inert solvent, at 100-180 (130-150) degrees C. Pref. w...

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Bibliographische Detailangaben
Hauptverfasser:	BOLTZE, KARL-HEINZ. DR, METZ, GUNTER., 7902 BLAUBEUREN, DE, LINDNER, KURT. DR., 5060 BERGISCH GLADBACH, DE, LOSCH, RAINER. DR., 5300 BONN, DE, WAHL, KARL-HEINZ. DR., 5000 KOELN, DE, WILK, HANS. DR., 5060 BERGISCH GLADBACH, DE, VOLLBRECHT, DIETER KLAUS. DR., 5060 BERGISCH GLADBACH, DE, SCHOEN, WERNER. DR., 5060 BERGISCH GLADBACH, DE
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	Prodn. of 2-(2-hydroxyethoxy)ethyl N-(alpha, alpha, alpha-trifluoro-m-tolyl)anthranilate (I) comprises reacting N-(alpha, alpha, alpha-trifluoro-m-tolyl)anthranilic acid (II) with diethylene glycol (III) in presence of acid catalyst, and opt. of inert solvent, at 100-180 (130-150) degrees C. Pref. water formed is removed azeotropically and (III) is used at 4-6 moles excess. The catalyst is pref. p-toluene-sulphonic acid and the solvent xylene or toluene. Reaction may be under an inert gas in a slight vacuum. (I) is a pharmaceutical (no details). One-step method is simpler than reaction of (II) with 2-(2-chloroethoxy) ethanol and gives a prod. easily purified by distn. The only by-product is water.