NEUE VINCINSAEUREDERIVATE UND VERFAHREN ZUR HERSTELLUNG DIESER VERBINDUNGEN

Vincinic acid derivatives of the general formula (I): wherein R represents hydrogen or an alkyl group containing from 2 to 6 carbon atoms, optionally substituted with hydroxyl, R1 represents hydroxyl, R2 represents hydrogen, or if R does not represent hydrogen, R1 and R2 together may form a valence...

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Bibliographische Detailangaben
Hauptverfasser:	KARPATI,EGON,DR, SZPORNY,LASZLO,DR, LOERINCZ,CSABA, SZASZ,KALMAN
Format:	Patent
Sprache:	ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Vincinic acid derivatives of the general formula (I): wherein R represents hydrogen or an alkyl group containing from 2 to 6 carbon atoms, optionally substituted with hydroxyl, R1 represents hydroxyl, R2 represents hydrogen, or if R does not represent hydrogen, R1 and R2 together may form a valence bond between two adjacent carbon atoms, and acid addition salts and quaternary salts thereof, especially the esters thereof, show valuable vasodilating activity and may be used as active ingredients of pharmaceutical compositions. The compounds are prepared by hydrolysis of vincine to vincinic acid, optionally followed by esterification and/or dehydration and/or salt formation.