N-ALKYL-N-ACYLDERIVATE VON THIENAMYCIN

N-ALKYL-N-ACYLDERIVATE VON THIENAMYCIN

Disclosed are N-alkyl- N-acyl derivatives of the antibiotic thienamycin having the following structural formula: wherein R1 is, inter alia, alkyl, alkenyl, aryl or aralkyl; and R2 is acyl. Such compounds, including their O- and carboxyl derivatives are useful as antibiotics. Also disclosed are proce...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: GRANT CHRISTENSEN,BURTON, JOSEPH LEANZA,WILLIAM
Format: Patent
Sprache:ger
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Disclosed are N-alkyl- N-acyl derivatives of the antibiotic thienamycin having the following structural formula: wherein R1 is, inter alia, alkyl, alkenyl, aryl or aralkyl; and R2 is acyl. Such compounds, including their O- and carboxyl derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds, and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.