CEPHALOSPORINDERIVATE, VERFAHREN ZU DEREN HERSTELLUNG UND DIESE ENTHALTENDE ARZNEIMITTEL

Antibiotic compounds of the general formula (I) [wherein R is a phenyl, thienyl or furyl group; Ra and Rb which may be the same or different, are each selected from hydrogen, C1-4 alkyl, C2-4 alkenyl, C3-7 cycloalkyl, phenyl, naphthyl, thienyl, furyl, carboxy, C2-5 alkoxycarbonyl and cyano, or Ra and Rb together with the carbon atom to which they are attached form a C3-7 cycloalkylidene or cycloalkenylidene group; m or n are each 0 or 1 such that the sum of m and n is 0 or 1; and R1 together with the nitrogen atom to which it is attached form a saturated or partially saturated 4-10 membered heterocyclic ring which may contain one or more further heteroatoms selected from 0,N and S and which may be substituted by a lower alkyl, lower alkoxy, lower acyloxy, lower alkoxycarbonyl, hydroxy, carboxy, amino, acylamino, substituted or unsubstituted carbamoyl or aryl group, or such a heterocyclic ring fused with a benzene ring] and non-toxic derivatives thereof, the compounds being syn isomers or existing as mixtures of syn and anti isomers.