VERFAHREN ZUR GEWINNUNG VON N-GLYKOSIL-DERIVATEN VON POLYENMAKROLIDEN SOWIE DEREN SALZEN, VORZUGSWEISE VON METHYLGLUKAMIN-SALZEN

The amino group-containing polyene macrolide is reacted with a mono- or oligosaccharide of the aldose or ketose series in an organic solvent or an organic solvent mixture. In order to be able to use an inexpensive, non-flammable solvent, the N-glycosyl derivative produced is precipitated from the re...

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Hauptverfasser:	TOMASZEWSKA,WLADYSLAWA WAGNER GEB, ZABLOCKA,EWA,DR.-BIOL. JAKOBS GEB, SIKORSKA,DANUTA,DR.-BIOL. ROSLIK-KAMINSKA GEB, MAKAROWSKA,ZOFIA PLOCIENNIK GEB, BOROWSKI,JAN,DR, FALKOWSKI,LEONARD,DR, BOJARSKA,HALINA,DR.. DAHLIG GEB, PAWLAK,JAN, KOWSZYK,ZUZANNA,DR.. KOWSZYK-GINDIFER GEB, GOLIK,JERZY,DR, KOLODZIEJCZYK,PAWEL,DR, BYLEC,ELZBIETA, ZIELINSKI,JAN,DR
Format:	Patent
Sprache:	ger
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	The amino group-containing polyene macrolide is reacted with a mono- or oligosaccharide of the aldose or ketose series in an organic solvent or an organic solvent mixture. In order to be able to use an inexpensive, non-flammable solvent, the N-glycosyl derivative produced is precipitated from the reaction medium by means of water or an aqueous solution of an inorganic salt, purified by crystallisation from a higher alcohol, and optionally converted into a salt.