Anxiolytic and sedative triazolo-thieno-diazepine(s) - with 8-iodo-6-phenyl substituents

Triazolo-thieno-1,4-diazepins of formula (I) and their acid-addn. salts are new (where R2 is H, Cl or Br; R3 is Cl, Br, -OMe, 3-6C cycloalkyl, 5-6 membered satd. or unsatd. ring contg. O, S or N; or when R2 is H or Br, R3 may be Me). (I) are anxiolytic and sedative agents. A typical cpd., 8-iodo-1-c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	LANGBEIN,ADOLF,DR, BOEKE,KARIN,DR, JOSEF,KUHN,FRANZ, WEBER,KARL-HEINZ,DR, LEHR,ERICH,DR
Format:	Patent
Sprache:	eng ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page
container_issue
container_start_page
container_title
container_volume
creator	LANGBEIN,ADOLF,DR BOEKE,KARIN,DR JOSEF,KUHN,FRANZ WEBER,KARL-HEINZ,DR LEHR,ERICH,DR
description	Triazolo-thieno-1,4-diazepins of formula (I) and their acid-addn. salts are new (where R2 is H, Cl or Br; R3 is Cl, Br, -OMe, 3-6C cycloalkyl, 5-6 membered satd. or unsatd. ring contg. O, S or N; or when R2 is H or Br, R3 may be Me). (I) are anxiolytic and sedative agents. A typical cpd., 8-iodo-1-cyclohexyl-6-(2-chlorophenyl)-4H-s-triazolo 3,4-c thieno- 2,3-e -1,4-diazepin, was prepd. by treating 8-iodo-6-(2chlorophenyl)-1-cyclohexylthieno 2,3-f -tri-azolo 3,4-- a -4,1-oxazepin in conc. Hbr with NH3, treating the prod. with SOCl2 themn NH4OH and KMnO4.
format	Patent
fullrecord	<record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_DE2703304A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>DE2703304A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_DE2703304A13</originalsourceid><addsrcrecordid>eNqNyjEKwkAQQNE0FqLeYUotBqIRtQ0a8QAWdmHNjuzAsrM4EzWeXgsPYPV58MfFpU4vljgYd-CSByXvjB8Edmf3lihogSkJ-i8pc6K5LgDhyRZghyxecIM5UBoiaH9VY-spmU6L0c1FpdmvkwKOzXl_QsrSkmbXUSJrD81qW1ZVua6X1R_LBwhNOWk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Anxiolytic and sedative triazolo-thieno-diazepine(s) - with 8-iodo-6-phenyl substituents</title><source>esp@cenet</source><creator>LANGBEIN,ADOLF,DR ; BOEKE,KARIN,DR ; JOSEF,KUHN,FRANZ ; WEBER,KARL-HEINZ,DR ; LEHR,ERICH,DR</creator><creatorcontrib>LANGBEIN,ADOLF,DR ; BOEKE,KARIN,DR ; JOSEF,KUHN,FRANZ ; WEBER,KARL-HEINZ,DR ; LEHR,ERICH,DR</creatorcontrib><description>Triazolo-thieno-1,4-diazepins of formula (I) and their acid-addn. salts are new (where R2 is H, Cl or Br; R3 is Cl, Br, -OMe, 3-6C cycloalkyl, 5-6 membered satd. or unsatd. ring contg. O, S or N; or when R2 is H or Br, R3 may be Me). (I) are anxiolytic and sedative agents. A typical cpd., 8-iodo-1-cyclohexyl-6-(2-chlorophenyl)-4H-s-triazolo 3,4-c thieno- 2,3-e -1,4-diazepin, was prepd. by treating 8-iodo-6-(2chlorophenyl)-1-cyclohexylthieno 2,3-f -tri-azolo 3,4-- a -4,1-oxazepin in conc. Hbr with NH3, treating the prod. with SOCl2 themn NH4OH and KMnO4.</description><edition>2</edition><language>eng ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>1978</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19780810&DB=EPODOC&CC=DE&NR=2703304A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19780810&DB=EPODOC&CC=DE&NR=2703304A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LANGBEIN,ADOLF,DR</creatorcontrib><creatorcontrib>BOEKE,KARIN,DR</creatorcontrib><creatorcontrib>JOSEF,KUHN,FRANZ</creatorcontrib><creatorcontrib>WEBER,KARL-HEINZ,DR</creatorcontrib><creatorcontrib>LEHR,ERICH,DR</creatorcontrib><title>Anxiolytic and sedative triazolo-thieno-diazepine(s) - with 8-iodo-6-phenyl substituents</title><description>Triazolo-thieno-1,4-diazepins of formula (I) and their acid-addn. salts are new (where R2 is H, Cl or Br; R3 is Cl, Br, -OMe, 3-6C cycloalkyl, 5-6 membered satd. or unsatd. ring contg. O, S or N; or when R2 is H or Br, R3 may be Me). (I) are anxiolytic and sedative agents. A typical cpd., 8-iodo-1-cyclohexyl-6-(2-chlorophenyl)-4H-s-triazolo 3,4-c thieno- 2,3-e -1,4-diazepin, was prepd. by treating 8-iodo-6-(2chlorophenyl)-1-cyclohexylthieno 2,3-f -tri-azolo 3,4-- a -4,1-oxazepin in conc. Hbr with NH3, treating the prod. with SOCl2 themn NH4OH and KMnO4.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1978</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyjEKwkAQQNE0FqLeYUotBqIRtQ0a8QAWdmHNjuzAsrM4EzWeXgsPYPV58MfFpU4vljgYd-CSByXvjB8Edmf3lihogSkJ-i8pc6K5LgDhyRZghyxecIM5UBoiaH9VY-spmU6L0c1FpdmvkwKOzXl_QsrSkmbXUSJrD81qW1ZVua6X1R_LBwhNOWk</recordid><startdate>19780810</startdate><enddate>19780810</enddate><creator>LANGBEIN,ADOLF,DR</creator><creator>BOEKE,KARIN,DR</creator><creator>JOSEF,KUHN,FRANZ</creator><creator>WEBER,KARL-HEINZ,DR</creator><creator>LEHR,ERICH,DR</creator><scope>EVB</scope></search><sort><creationdate>19780810</creationdate><title>Anxiolytic and sedative triazolo-thieno-diazepine(s) - with 8-iodo-6-phenyl substituents</title><author>LANGBEIN,ADOLF,DR ; BOEKE,KARIN,DR ; JOSEF,KUHN,FRANZ ; WEBER,KARL-HEINZ,DR ; LEHR,ERICH,DR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_DE2703304A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; ger</language><creationdate>1978</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>LANGBEIN,ADOLF,DR</creatorcontrib><creatorcontrib>BOEKE,KARIN,DR</creatorcontrib><creatorcontrib>JOSEF,KUHN,FRANZ</creatorcontrib><creatorcontrib>WEBER,KARL-HEINZ,DR</creatorcontrib><creatorcontrib>LEHR,ERICH,DR</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LANGBEIN,ADOLF,DR</au><au>BOEKE,KARIN,DR</au><au>JOSEF,KUHN,FRANZ</au><au>WEBER,KARL-HEINZ,DR</au><au>LEHR,ERICH,DR</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Anxiolytic and sedative triazolo-thieno-diazepine(s) - with 8-iodo-6-phenyl substituents</title><date>1978-08-10</date><risdate>1978</risdate><abstract>Triazolo-thieno-1,4-diazepins of formula (I) and their acid-addn. salts are new (where R2 is H, Cl or Br; R3 is Cl, Br, -OMe, 3-6C cycloalkyl, 5-6 membered satd. or unsatd. ring contg. O, S or N; or when R2 is H or Br, R3 may be Me). (I) are anxiolytic and sedative agents. A typical cpd., 8-iodo-1-cyclohexyl-6-(2-chlorophenyl)-4H-s-triazolo 3,4-c thieno- 2,3-e -1,4-diazepin, was prepd. by treating 8-iodo-6-(2chlorophenyl)-1-cyclohexylthieno 2,3-f -tri-azolo 3,4-- a -4,1-oxazepin in conc. Hbr with NH3, treating the prod. with SOCl2 themn NH4OH and KMnO4.</abstract><edition>2</edition><oa>free_for_read</oa></addata></record>
fulltext	fulltext_linktorsrc
identifier
ispartof
issn
language	eng ; ger
recordid	cdi_epo_espacenet_DE2703304A1
source	esp@cenet
subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
title	Anxiolytic and sedative triazolo-thieno-diazepine(s) - with 8-iodo-6-phenyl substituents
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T15%3A17%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=LANGBEIN,ADOLF,DR&rft.date=1978-08-10&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EDE2703304A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true