Penicillanic acid and cephalosporanic acid derivs. - are antibiotics esp. effective against Gram negative microorganisms e.g. Pseudomonas and Proteus

Penicillanic acid and cephalosporanic acid derivs. - are antibiotics esp. effective against Gram negative microorganisms e.g. Pseudomonas and Proteus

Beta-Lactam cpds. of formula (I) and their acceptable salts and esters are new. In (I) X is of formula (H) or (J) R1 is H, opt. substd. alkyl, aryl or heterocyclic gp; R2 and R4 are H or lower alkyl; R3 and R5 are H, halogen, lower alkyl or alkoxy; A is CH or N; B is a single bond or methyleneoxy; C...

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Bibliographische Detailangaben
Hauptverfasser: SCHORR,MANFRED,.DR, WORM,MANFRED,.DR, SCHMITT,WILFRIED, SCHRINNER,ELMAR,DR
Format: Patent
Sprache:eng ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Beta-Lactam cpds. of formula (I) and their acceptable salts and esters are new. In (I) X is of formula (H) or (J) R1 is H, opt. substd. alkyl, aryl or heterocyclic gp; R2 and R4 are H or lower alkyl; R3 and R5 are H, halogen, lower alkyl or alkoxy; A is CH or N; B is a single bond or methyleneoxy; C is a single bond, or phenylene; D is a single bond, lower alkylene or oxyalkylene; Y is opt. substd. Ph, opt. substd. monocyclic aromatic heterocyclic gp. or dihydrophenyl; and Z is of formula (K) or (L) E is H, acetoxy of S-G; G is an opt. substd. heterocyclic gp.). Typical cpds. are 6 D-2-(4-(benzimidazol-2-yl)phenoxyacetylamino-2-phenyl-acetylami- no -penicillanic acid and 7 D-2-(2-(4-fluorophenyl)-benzimidazol-5-yl-carbonylamino)-2-phen- ylacetyl-amino -cephalosporanic acid.