Ergoline derivs. e.g. ergotoxine and ergometrine prodn. - by fermentation of Claviceps purpurea IMET PA 130

Ergoline derivs. e.g. ergotoxine and ergometrine prodn. - by fermentation of Claviceps purpurea IMET PA 130

The fermentative prodn. of ergoline derivs. (esp. alkaloids and 9,10-dihydro alkaloids of the ergotoxine group, and ergometrine) comprises culturing conidiospores of Claviceps purpurea (Fr.) Tul. IMET PA 130 under saprophytic conditions. These spores are used as the inoculum for submerged cultures f...

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Hauptverfasser: KNOTHE,EDDA, DAUTH,CHRISTOPH,.DR, GRAWERT,WERNER, BREUEL,KLAUS,DR, GROEGER,DETLEV,DR, SCHIRUTSCHKE,RUDOLF, NORDMANN,GISELA,-BIOLOGIN, BOROWSKI,EVA, VOLZKE,KLAUS-DIETER,-BIOLOGE, HOEHNE,LISELOTTE, BRAUN,KLAUS, MUELLER,MONIKA, ERGE,DIETER,DR
Format: Patent
Sprache:eng ; ger
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HETEROCYCLIC COMPOUNDS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
SPIRITS
VINEGAR
WINE
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Zusammenfassung:The fermentative prodn. of ergoline derivs. (esp. alkaloids and 9,10-dihydro alkaloids of the ergotoxine group, and ergometrine) comprises culturing conidiospores of Claviceps purpurea (Fr.) Tul. IMET PA 130 under saprophytic conditions. These spores are used as the inoculum for submerged cultures for alkaloid synthesis. At the end of culturing, the alkaloids formed are recovered from teh filtrate or mycelium, or directly from the culture fluid, opt. 9,10-dihydrogenated, and converted into therapeutically suitable acid addn. salts.