(1,3)-Diaza-(2)-phospha-cyclohexane derivs. - with pharmacodynamic and germicidal activity, prepd. by reacting phosphordiamide cpds. with malonyl chloride derivs

(1,3)-Diaza-(2)-phospha-cyclohexane derivs. - with pharmacodynamic and germicidal activity, prepd. by reacting phosphordiamide cpds. with malonyl chloride derivs

New 1,3-diaza-2-phospha-cyclohexane derivs. are of formula (I) (where R1 is alkyl, cycloalkyl or aryl; and R2, R3 R4 and R5 are H, alkyl, cycloalkyl, alkenyl or aryl). (I) are phosphorous analogues of barbituric acids. Specific cpds. (I) include 1,3-di-n-propyl-2,4,6-trioxo-2-ethoxy 1,3-diaza-2-phos...

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Hauptverfasser: LENIG,A.R, STOCK,W.,DR, ROTH,H.J.,DR
Format: Patent
Sprache:eng ; ger
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:New 1,3-diaza-2-phospha-cyclohexane derivs. are of formula (I) (where R1 is alkyl, cycloalkyl or aryl; and R2, R3 R4 and R5 are H, alkyl, cycloalkyl, alkenyl or aryl). (I) are phosphorous analogues of barbituric acids. Specific cpds. (I) include 1,3-di-n-propyl-2,4,6-trioxo-2-ethoxy 1,3-diaza-2-phospha-cyclohexane. In an example, this is prepd. by reacting malonyl chloride with phosphoric acid ethyl ester bis-n-propyl-amide in Et2O.