AMINOSAEUREPRAEPARATE FUER LEBERKRANKE PATIENTEN

Amino acid formulations for administration to human patients with liver disease comprise mixtures of essential amino acids combined in novel relative proportions, and preferably also include non-essential amino acids. In particular, the combined molar proportions of isoleucine, leucine, and valine a...

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Bibliographische Detailangaben
Hauptverfasser:	E. FISCHER,JOSEF, LOUIS WESTMAN,THOMAS, HERMAN DEINDOERFER,FRED, NOBUO YOSHIMURA,NORMAN
Format:	Patent
Sprache:	ger
Schlagworte:	FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Zusammenfassung:	Amino acid formulations for administration to human patients with liver disease comprise mixtures of essential amino acids combined in novel relative proportions, and preferably also include non-essential amino acids. In particular, the combined molar proportions of isoleucine, leucine, and valine are from 40 to 300 times the molar proportion of tryptophan and from 15 to 135 times the molar proportion of phenylalanine, or phenylalanine and tyrosine. The formulations may be adapted for either intravenous or oral administration, but the preferred method of administration is by hyperalimentation infusion. The formulations and method can be utilized to provide nutritional support for liver diseased patients while reducing the incidence and severity of hepatic encephalopathy, and/or as primary therapy for treatment of hepatic encephalopathy.