ANTHELMINTHISCH WIRKSAME 2-CARBALKOXYAMINO-5(6)-PHENYL-SULFONYLOXY- BENZIMIDAZOLE UND VERFAHREN ZU IHRER HERSTELLUNG

Anthelmintically active 2-carbalkoxyamino-5(6)-phenylsulphonyloxy-benzimidazoles of the accompanying formula I, in which R1 denotes alkyl having 1 to 4 carbon atoms; and R2 and R3 in each case independently of one another denote hydrogen, hydroxyl, alkoxy having 1 to 4 carbon atoms, halogen, trifluo...

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Hauptverfasser: LOEWE,HEINZ,DR, DUEWEL,DIETER,DR, KIRSCH,REINHARD,DR, URBANIETZ,JOSEF
Format: Patent
Sprache:ger
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Zusammenfassung:Anthelmintically active 2-carbalkoxyamino-5(6)-phenylsulphonyloxy-benzimidazoles of the accompanying formula I, in which R1 denotes alkyl having 1 to 4 carbon atoms; and R2 and R3 in each case independently of one another denote hydrogen, hydroxyl, alkoxy having 1 to 4 carbon atoms, halogen, trifluoromethyl, alkyl having 1 to 4 carbon atoms, carbalkoxy having 1 to 4 carbon atoms in the alkoxy radical or CN are prepared by reacting an appropriate 2-carbalkoxyamino- 5(6)-hydroxybenzimidazole with an appropriately substituted benzenesulphonyl halide in the presence of a base. These compounds are distinguished by a good anthelmintic activity and are useful chemotherapeutics for the control of parasitic disorders in humans and animals, in particular those which are caused by helminths.