1-Substd. ethyl 4-(carboxiamido-or carbamoyl-alkyl)-biphenyl ethers - prepd. e.g. by reacting 4-(4-substd. phenyl) phenols with 1-substd. alkyl halides

1-Substd. ethyl 4-(carboxiamido-or carbamoyl-alkyl)-biphenyl ethers - prepd. e.g. by reacting 4-(4-substd. phenyl) phenols with 1-substd. alkyl halides

Biphenyl ethers of formula (I) (where R1 is 1-6C alkyl, 2-6C alkenyl, 3-6C cycloalkyl, phenyl opt. mono- or di- substd. by halogen, 1-3C alkyl or 1-3C alkoxy, aralkyl, aralkenyl, pyridyl, isoxazolyl or pyrazolyl; R2 is H or 1-4C alkyl; R3 is CH2OH, COOH, 2-7C alkoxycarbonyl, 4-8C cycloalkoxy-carbony...

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Hauptverfasser: GRISS,GERHARD,.DR, HURNAUS,RUDOLF,.DR, SAUTER,ROBERT,.DR, EISELE,BERNHARD,.DR, GRELL,WOLFGANG,.DR
Format: Patent
Sprache:eng ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Biphenyl ethers of formula (I) (where R1 is 1-6C alkyl, 2-6C alkenyl, 3-6C cycloalkyl, phenyl opt. mono- or di- substd. by halogen, 1-3C alkyl or 1-3C alkoxy, aralkyl, aralkenyl, pyridyl, isoxazolyl or pyrazolyl; R2 is H or 1-4C alkyl; R3 is CH2OH, COOH, 2-7C alkoxycarbonyl, 4-8C cycloalkoxy-carbonyl or 8-9C aralkoxycarbonyl; A is -CO-NH- or -NH-CO-; and n is 1, 2 or 3), e.g. 2-methyl-2-/4'-/2-(2-methoxy-5-chlorobenzamido)ethyl/-4-biphenyly- loxy)-propionic acid ethyl ester, and salts of (I; R3 = COOH) with inorganic or organic bases are new cpds. (I) have cholesterol and triglyceride lowering properties superior to those of the cpds. disclosed in DT 2149070 and GB 8060303 and 1121722.