1-Alkyl-2-(pyridylthiomethyl)-5-nitroimidazoles prodn. - from corresp. 2-(acyloxymethyl or aralkoxymethyl) cpds. and mercapto pyridines, useful as antiprotozoals

Process for preparing 5-nitroimidazoles derivs. of formula (I) comprises reacting 2-(acyloxy- or aralkoxymethyl)imidazoles (II) with mercapto pyridine (N-oxides) (R=CH2 or C2H5; n=0 or 1; X=acyloxy or aralkoxy; Y=H or alkali metal). (I) are antiprotozoals useful in human or veterinary medicine for c...

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Hauptverfasser:	RAETHER,WOLFGANG,DR, WINKELMANN,ERHARDT,DR
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Sprache:	eng ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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creator	RAETHER,WOLFGANG,DR WINKELMANN,ERHARDT,DR
description	Process for preparing 5-nitroimidazoles derivs. of formula (I) comprises reacting 2-(acyloxy- or aralkoxymethyl)imidazoles (II) with mercapto pyridine (N-oxides) (R=CH2 or C2H5; n=0 or 1; X=acyloxy or aralkoxy; Y=H or alkali metal). (I) are antiprotozoals useful in human or veterinary medicine for control of e.g. Trichomonas vaginalis and Entamoeba histolytica. They are more active than metronidazole and can be applied orally or topically, the usual oral dose being 10-750 mg/day.
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(I) are antiprotozoals useful in human or veterinary medicine for control of e.g. Trichomonas vaginalis and Entamoeba histolytica. 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(I) are antiprotozoals useful in human or veterinary medicine for control of e.g. Trichomonas vaginalis and Entamoeba histolytica. 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(I) are antiprotozoals useful in human or veterinary medicine for control of e.g. Trichomonas vaginalis and Entamoeba histolytica. They are more active than metronidazole and can be applied orally or topically, the usual oral dose being 10-750 mg/day.</abstract><edition>2</edition><oa>free_for_read</oa></addata></record>
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
title	1-Alkyl-2-(pyridylthiomethyl)-5-nitroimidazoles prodn. - from corresp. 2-(acyloxymethyl or aralkoxymethyl) cpds. and mercapto pyridines, useful as antiprotozoals
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