DE2434017

DE2434017

1473090 Cephalosporins LILLY INDUSTRIES Ltd 18 July 1974 [19 July 1973] 34337/73 Heading C2C A 7 - α - aminoacetamido - cephalosporin - 4- carboxylic acid is made by reacting a 7-aminocephalosporin-4-carboxylic acid ester with a reactive derivative of an α-aminoacetic acid, in which the amino group...

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Bibliographische Detailangaben
Hauptverfasser: SPENCE, THOMAS WILLIAM MATCHES, GREAT SANKEY, WARRINGTON, CHESHIRE, DAVISON, MICHAEL, RAINFORD, ST. HELENS, LANCASHIRE, FRANKHAM, DAVID BINFIELD, HELSBY, WARRINGTON
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:1473090 Cephalosporins LILLY INDUSTRIES Ltd 18 July 1974 [19 July 1973] 34337/73 Heading C2C A 7 - α - aminoacetamido - cephalosporin - 4- carboxylic acid is made by reacting a 7-aminocephalosporin-4-carboxylic acid ester with a reactive derivative of an α-aminoacetic acid, in which the amino group is protected by forming an enamine with a #-dicarbonyl compound; removing the amino protecting group from the product; adding sufficient hydrazine or its derivative (e.g. semicarbazide) to prevent reaction of the liberated dicarbonyl compound; and, if desired de-esterifying the resulting 7-α- aminoacetamido compound.