Hypolipaemic N(6)-monosubstd. adenosines - prepd. by reacting 6-chloro-9-ribofuranosyl-purine with secondary amines

Hypolipaemic N(6)-monosubstd. adenosines - prepd. by reacting 6-chloro-9-ribofuranosyl-purine with secondary amines

Adenosines of formula (I): (where R1 and R2 are identical and are cyclopropyl, phenyl or benzyl, or R1 is CH3 and R2 is cyclopropylmethyl, cyclohexylmethyl, cyclooctylmethyl, 3-cyclohexenylmethyl, 6-methyl-3-cyclohexenyl-methyl, 5-norbornene-2-ylmethyl, 4-dimethylamino-benzyl, 2-chloro- 4-dimethylam...

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Bibliographische Detailangaben
Hauptverfasser: HOFRICHTER,GERNOT,DR.MED.VET, WERNER,HEINZ, HANS,ZSCHOCKE,RAINER, WAGNER,JOSEF,.ER.NAT
Format: Patent
Sprache:eng ; ger
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:Adenosines of formula (I): (where R1 and R2 are identical and are cyclopropyl, phenyl or benzyl, or R1 is CH3 and R2 is cyclopropylmethyl, cyclohexylmethyl, cyclooctylmethyl, 3-cyclohexenylmethyl, 6-methyl-3-cyclohexenyl-methyl, 5-norbornene-2-ylmethyl, 4-dimethylamino-benzyl, 2-chloro- 4-dimethylaminobenzyl or diphenylmethyl), e.g. N6 - (1-methyl-2-cyclopropyl-ethyl)-adenosine, and their acid addn. salts was pharmacologically tolerable acids are new cpds. (I) are well tolerated hypolipaemic agents which can be used for lowering elevated blood levels of cholesterol and neutral fats. (I) are prepd. by reacting 6-chloro-9-beta-D-ribofuranosyl-9H-purine (II) with an amine of the formula H2N-CHR1R2.