ANTIBIOTICUM BM 123 UND VERFAHREN ZU SEINER HERSTELLUNG

1439668 Antibiotic BM123 AMERICAN CYANAMID CO 10 Sept 1973 [12 Oct 1972] 42535/73 Heading C2A Antibiotic BM123 is prepared by cultivating a microorganism having the characteristics of Nocardia sp. NRRL 5646 or mutants thereof in an aqueous nutrient medium containing assimilable sources of carbon, ni...

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Hauptverfasser:	JAMES MARTIN,JOHN HENRY EDWARD, NORMAN PORTER,JOHN, DAVID TRESNER,HOMER
Format:	Patent
Sprache:	ger
Schlagworte:	ADHESIVES BEER BIOCHEMISTRY CHEMISTRY COMPOUNDS OF UNKNOWN CONSTITUTION DYES ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE LAKES MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MISCELLANEOUS APPLICATIONS OF MATERIALS MISCELLANEOUS COMPOSITIONS MORDANTS MUTATION OR GENETIC ENGINEERING NATURAL RESINS ORGANIC CHEMISTRY ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES PAINTS POLISHES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Zusammenfassung:	1439668 Antibiotic BM123 AMERICAN CYANAMID CO 10 Sept 1973 [12 Oct 1972] 42535/73 Heading C2A Antibiotic BM123 is prepared by cultivating a microorganism having the characteristics of Nocardia sp. NRRL 5646 or mutants thereof in an aqueous nutrient medium containing assimilable sources of carbon, nitrogen and inorganic salts under submerged aerobic conditions until substantial antibacterial activity is imparted to the medium, and then recovering BM123 therefrom. The antibiotic exists in three forms, designated BM123α, BM123# and BM123#. Antibiotic BM123α is characterized by (a) having an optical rotation (C= 1.00 in water); (b) having the following elemental analysis (per cent); C, 33.89; H, 5.71; N, 11.88; O, 35.40; and (c) the infra-red absorption spectrum indicated in Fig. 1 (not shown). Antibiotic BM123# is characterized by (a) having an optical rotation (C=1.25 in water); (b) having the following elemental analysis: C, 47.53; H, 7.39; N, 16.54; ash, 1.04; and (c) the infra-red absorption spectrum indicated in Fig. 2 (not shown). Antibiotic BM123 # is characterized by (a) having an optical rotation (C= 1.004 in water); (b) having the following elemental analysis: C, 46.13; H, 6.65; N, 17.00; O, 24.96; ash, 0.90; and (c) the infra-red absorption spectrum indicated in Fig. 3 (not shown). These antibiotics may be incorporated with suitable carriers into various pharmaceutical forms.