2-(0-Nitro-phenyl)-1,3-propan-diol prodn. - from 2-(0-nitrophenyl)-ethanol and formaldehyde

2-(0-Nitro-phenyl)-1,3-propan-diol prodn. - from 2-(0-nitrophenyl)-ethanol and formaldehyde

The reaction is carried out in the liq. phase at 24-40 (25-35) degrees C in the presence of dialkyl sulphoxide (Me2SO) or N-dialkyl-substd. amide and strong base (I) (alkali metal hydroxide, e.g. solid KOH), using 1 mole 2-(o-nitrophenyl)-ethanol, 1.2-1.5 mole HCHO and 0.5-0.2 (0.07) mole (I); and t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: COLLIN, GERD, GRIGOLEIT, GEORG, OBERKOBUSCH, RUDOLF
Format: Patent
Sprache:eng ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The reaction is carried out in the liq. phase at 24-40 (25-35) degrees C in the presence of dialkyl sulphoxide (Me2SO) or N-dialkyl-substd. amide and strong base (I) (alkali metal hydroxide, e.g. solid KOH), using 1 mole 2-(o-nitrophenyl)-ethanol, 1.2-1.5 mole HCHO and 0.5-0.2 (0.07) mole (I); and the resultant 2-(o-nitrophenyl)-1,3-propandiol (II) is isolated in the usual way after removing the alkali (by ion exchange). (II) can be converted via the amino cpd. to 3-methylindole and indole in high yield. The process is suitable for batch or continuous operation on an industrial scale and is simple and cheap.