DE2307543

DE2307543

A copper-free form of phleomycin-bleomycin group antibiotics with very small residual copper content and unreduced antitumor activity may be obtained in high yields by contacting an aqueous solution containing a copper-containing form of said antibiotics with a non-ionexchangeable macroreticular res...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MURAOKA, YASUHIKO, MIZUGUCHI, SHIGERU, FUJII, AKIO, TAKITA, TOMOHISA, ASAKA, UMEZAWA, HAMAO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
COMPOUNDS OF UNKNOWN CONSTITUTION
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PEPTIDES
SUGARS
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Beschreibung
Zusammenfassung:A copper-free form of phleomycin-bleomycin group antibiotics with very small residual copper content and unreduced antitumor activity may be obtained in high yields by contacting an aqueous solution containing a copper-containing form of said antibiotics with a non-ionexchangeable macroreticular resin to allow said antibiotics to be adsorbed on the resin, contacting the resin with an aqueous solution containing a chelating agent to release copper from said antibiotics, and then with an organic solvent containing water to elute the adsorbed antibiotics.