NEUE PYRIMIDO ECKIGE KLAMMER AUF 5,4-D ECKIGE KLAMMER ZU PYRIMIDINE

1432731 Pyrimidopyrimidines DR KARL THOMAE GmbH 7 Jan 1974 [8 Jan 1973] 00586/74 Heading C2C Compounds of the general formula (R 1 = C 1 -C 3 alkoxy-(C 2 -C 3 alkyl); R 2 = C 2 -C 4 hydroxyalkyl or C 3 dihydroxyalkyl; R 3 = C 1 -C 3 alkoxy-(C 2 -C 3 alkyl) or C 2 -C 3 hydroxyalkyl; R 4 = di(C 2 -C 4 alkyl)amino, diallylamino, piperidino or hexamethyleneimino) and their acid addition salts are prepared by (a) reacting a compound of the formula (one Z 1 = replaceable atom or group and the other = NR 1 R 2 or NR 2 R 3 , or both symbols Z 1 = replaceable atoms or groups) with R 1 R 2 NH or R 2 R 3 NH or (b) reacting a compound of the formula (one Z 2 = replaceable group and the other = R 4 , or both symbols Z 2 = replaceable groups) with R 4 H, optionally followed in either case by salt formation. The above compounds increase blood pressure, affect blood oxygen transport, inhibit thrombocyte aggregation, enhance blood flow and are coronary dilators. They may be administered in the form of pharmaceutical preparations containing them in association witha carrier.