Saponification of pregnane series esters - using silica gel
17 alpha-Esters or 17 alpha, 21-diesters of 11 beta, 17 alpha, 21-triols of the pregnane series are prepd. by treating an 11 beta, 21-bis(trihaloacetoxy)-17 alpha, 21-diol dialkanoate with silica gel in an inert solvent. The trihaloacetoxy gp. is pref. CF3COO. The products have physiological e.g. an...
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| Format: | Patent |
| Sprache: | eng ; ger |
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| Zusammenfassung: | 17 alpha-Esters or 17 alpha, 21-diesters of 11 beta, 17 alpha, 21-triols of the pregnane series are prepd. by treating an 11 beta, 21-bis(trihaloacetoxy)-17 alpha, 21-diol dialkanoate with silica gel in an inert solvent. The trihaloacetoxy gp. is pref. CF3COO. The products have physiological e.g. antiphlogistic and antiproliferative, activity. |
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