DE2136325

1346037 2 - (Indanyl - 41 amino) - #2- imidazoline NORDMARK-WERKE GmbH 18 July 1972 [21 July 1971] 33461/72 Heading C2C 2 - (Indanyl - 41 - amino) - #2 - imidazoline and its acid addition salts, are prepared (1) by reacting a compound II in which R is or CN where R 1 is C 1-6 alkyl with ethylene diamine or a monosalt thereof (2) subjecting N-(4-indanyl)-N1-(#-aminoethyl) urea or thiourea to ring closure by heating to a temperature between 130-200‹ C. C. (3) reacting 4-aminoindene with a compound (V) in which R 1 is C 1-6 alkyl or with bis-(2-oxo-1- imidazoledinyl)phosphuryl chloride (4) reacting an indenyl-4-isocyanide dihalogenide in which the halogen in chlorine or bromine with ethylene diamine or (5) partially hydrogenating 2-(indenyl - 41 - amino) - #2 - imidazoline either with a catalyst (Raney-Nickel) at elevated temperature and pressure or using nascent hydrogen. 2 - (Indenyl - 41 - amino) - #2 - imidazoline and its acid-addition salts possess vasoconstrictor properties and form with a carrier or diluent a pharmaceutical composition.