4'-oxo-rhamnosyl-glycosides - cardiotonics with improved resorption

4'-oxo-rhamnosyl-glycosides - cardiotonics with improved resorption

Title cpds. of formula (I): (where R1 and R2 are H or R1 and R2 is in which A is H or lower alkyl and B is lower alkyl or phenyl, or CAB is a 6- or 7-membered cycloaliphatic ring; R3 and R4 are H or R3 + R4 is oxo; R5 is the cardenolide ring or the bufadienolide ring; and R6 is H and R7 is OH or H,...

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Bibliographische Detailangaben
Hauptverfasser: KOBINGER,WALTER,DR, HEIDER,JOACHIM,.DR, EBERLEIN,WOLFGANG,.DR
Format: Patent
Sprache:eng ; ger
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Beschreibung
Zusammenfassung:Title cpds. of formula (I): (where R1 and R2 are H or R1 and R2 is in which A is H or lower alkyl and B is lower alkyl or phenyl, or CAB is a 6- or 7-membered cycloaliphatic ring; R3 and R4 are H or R3 + R4 is oxo; R5 is the cardenolide ring or the bufadienolide ring; and R6 is H and R7 is OH or H, when R5 is the cardenolide ring, or together with R6 signifies a double bond), which have good cardiotonic activity with better resorption than corresp. non-oxidised rhamnosyl-glycosides, and which are also as intermediates for a variety of other cardioglycoside derivs.