Amino-hydroxypropyl-coumarins - with coronary dilating activity

Amino-hydroxypropyl-coumarins - with coronary dilating activity

Coumarins of formula (I): (where R1 and R2 are H or is not >4C alkyl in which one H-atom can be replaced by an OH gp., at least one of R1 and R2 being other than H, or NR1R2 is a 5- or 6- membered heterocycle, and R3 is not >3C alkyl) and their salts with pharmacologically tolerable acids are...

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Bibliographische Detailangaben
Hauptverfasser: BOLTZE,KARL-HEINZ,.DR, HEINZ,BECKER,KARL, SEIDEL,PETER-RUDOLF,.DR, LORENZ,DIETRICH,DR
Format: Patent
Sprache:eng ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Coumarins of formula (I): (where R1 and R2 are H or is not >4C alkyl in which one H-atom can be replaced by an OH gp., at least one of R1 and R2 being other than H, or NR1R2 is a 5- or 6- membered heterocycle, and R3 is not >3C alkyl) and their salts with pharmacologically tolerable acids are strongly active coronary dilators which are more resistant to in vivo degradation than the known coronary dilator carbocromene.