Production of alkyl tetronate esters used as intermediates for pharmaceuticals

Production of alkyl tetronate esters used as intermediates for pharmaceuticals

Preparation of alkyl tetronate esters of formula (I) comprises reacting an alkyl 4-haloacetoacetate of formula (II) with a base to form a tetronate of formula (III) and reacting (III) with a dialkyl sulphate of formula (IV) R1O-SO2-OR1 (IV) R1 = 1-6C alkyl (preferably Me); X = Cl, Br or I (preferabl...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: SCHROEER, JOSEF., SUSTEN, CH, POLLOCK, SIMON, VISP, CH, GRIFFITHS, GARETH., VISP, CH
Format: Patent
Sprache:eng ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Preparation of alkyl tetronate esters of formula (I) comprises reacting an alkyl 4-haloacetoacetate of formula (II) with a base to form a tetronate of formula (III) and reacting (III) with a dialkyl sulphate of formula (IV) R1O-SO2-OR1 (IV) R1 = 1-6C alkyl (preferably Me); X = Cl, Br or I (preferably Cl); and R2 = 1-6C alkyl (preferably Et).