Amide des Cysteins als Inhibitoren der Farnesyltransferase

The invention relates to compounds of formula (I) which have inhibitory effects on farnesyl transferase. Some of these compounds present in vitro inhibition of farnesyl transferase at concentrations < 1 mu M. The compounds provided for in the invention have the general formula (I), in which n is between 0 and 3; R , R are H, alkyl, aryl, heteroaryl, acyl; R is H, halogen, alkyl, aryl, heteroaryl, arylalkyl, acyl, CN, NO2, R -X-; R is H, alkyl, aryl, heteroaryl, aralkyl, acyl; X is NH, O, S, SO2, NHSO2, OSO2; and A, B, C are organic rests. Die Erfindung betrifft Verbindungen der Formel I mit inhibitorischen Wirkungen auf die Farnesyltransferase. Einige Verbindungen zeigen eine in vitro Hemmung der Farnesyltransferase bei Konzentrationen < 1 muM. DOLLAR A Die erfindungsgemäßen Verbindungen haben die allgemeine Formel (I) DOLLAR F1 worin DOLLAR A n = 0-3; R·1·, R·2· = H, Alkyl, Aryl, Heteroaryl, Acyl; R·3· = H, Halogen, Alkyl, Aryl, Heteroaryl, Arylalkyl, Acyl, CN, NO¶2¶, R·4·-X-; R·4· = H, Alkyl, Aryl, Heteroaryl, Aralkyl, Acyl; X = NH, O, S, SO¶2¶, NHSO¶2¶, OSO¶2¶ und A, B, C = organische Reste sind.