Verfahren zur Herstellung von Filmtabletten mit Cyclophosphamid als Wirkstoff und daraus hergestellte Cyclophosphamid-Filmtablette

1. [sic] The invention relates to film-coated tablets with cyclophosphamide as active compound, which in the core comprise cyclophosphamide, one or more fillers, one or more dry binders but no preswollen starch, flow regulators and lubricants. According to a preferred embodiment of the invention, th...

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Bibliographische Detailangaben
Hauptverfasser: RAWERT, JUERGEN, SAUERBIER, DIETER, ENGEL, JUERGEN, WICHERT, BURKHARD
Format: Patent
Sprache:ger
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Zusammenfassung:1. [sic] The invention relates to film-coated tablets with cyclophosphamide as active compound, which in the core comprise cyclophosphamide, one or more fillers, one or more dry binders but no preswollen starch, flow regulators and lubricants. According to a preferred embodiment of the invention, the core of the film-coated tablet comprises as a filler lactose monohydrate, D-mannitol or CaHPO4, nonpreswollen cornstarch or microfine cellulose as a dry binder, highly disperse silica as a flow regulator and magnesium stearate, stearic acid, glycerol palmitostearate, polyethylene glycol, talc or glycerol monobeherate [sic] as a lubricant.