New acyl-(aryl- or hetero-aryl(carbonyl))aminoacid compounds

Modified amino acids of formula (I) and their tautomers, diastereomers, enantiomers and salts are new. R = 1-7C n-alkyl (optionally w-substituted by 4-10C cycloalkyl, phenyl, optionally partially hydrogenated heteroaryl etc.), optionally N-(alkyl- or phenylmethyl)-substituted 1-6C n-alkylamino (opti...

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Hauptverfasser:	WIENEN, WOLFGANG-BIOL. DR., 88400 BIBERACH, DE, RUDOLF, KLAUS. DR., 88400 BIBERACH, DE, HALLERMAYER, GERHARD., 88437 MASELHEIM, DE, EBERLEIN, WOLFGANG. DR., 88400 BIBERACH, DE, ENGEL, WOLARD. DR., 88400 BIBERACH, DE, PIEPER, HELMUT. DR., 88400 BIBERACH, DE, DOODS, HENRI., 88447 WARTHAUSEN, DE, ENTZEROTH, MICHAEL. DR., 88447 WARTHAUSEN, DE
Format:	Patent
Sprache:	eng ; ger
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TESTING
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Beschreibung
Zusammenfassung:	Modified amino acids of formula (I) and their tautomers, diastereomers, enantiomers and salts are new. R = 1-7C n-alkyl (optionally w-substituted by 4-10C cycloalkyl, phenyl, optionally partially hydrogenated heteroaryl etc.), optionally N-(alkyl- or phenylmethyl)-substituted 1-6C n-alkylamino (optionally w-substituted on the 1-6C alkyl by 4-10C cycloalkyl, phenyl, optionally partially hydrogenated heteroaryl etc.); X = O or H2; Z = CH2 or NR1; R1 = H, alkyl or phenylalkyl; R11 = H, 1-3C alkyl or benzyl; n = 0-2; m = 0-1; provided m and n are not both 0; R2 = phenyl, naphthyl, 1H-indol-3-yl (optionally 1-substituted by methyl, formyl or t-butoxycarbonyl), 4-imidazolyl, 1-methyl-4-imidazolyl, thienyl, 1H-indazol-3-yl, etc.; A = bond or NR8CHR9CO; R8 = H, alkyl or phenylalkyl; R9 = H or 1-5C alkyl (optionally w-substituted); R3 = H, 1-7C alkyl (optionally w-substituted by cycloalkyl, phenyl, pyridyl, diazinyl, OH, etc.); R4 = H or 1-3C alkyl (optionally substituted by phenyl or pyridyl); or NR3R4 = a cyclic group.