Streptomycin acylembonates as depot cpds

Sparingly soluble salts of streptomycin antibiotics with acyl-embonic acids the acyl being derived from a 2-5C aliphatic acid, are used as antitubercular depot cpds. which obviate frequent i.m. injections and ensure even serum levels. The acetyl-embonates of streptomycin and dihydrostreptomycin are...

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Hauptverfasser:	SOEDER,ALFONS,.DR, LOEWE,HEINZ,.DR, HOFFMANN,HINRICH,.DR, WAGNER,WOLF-HELMUT,DR.MED
Format:	Patent
Sprache:	eng ; ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS BOARDS, SUBSTATIONS, OR SWITCHING ARRANGEMENTS FOR THE SUPPLYOR DISTRIBUTION OF ELECTRIC POWER CHEMISTRY CONVERSION OR DISTRIBUTION OF ELECTRIC POWER DERIVATIVES THEREOF ELECTRICITY GENERATION METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SUGARS
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Zusammenfassung:	Sparingly soluble salts of streptomycin antibiotics with acyl-embonic acids the acyl being derived from a 2-5C aliphatic acid, are used as antitubercular depot cpds. which obviate frequent i.m. injections and ensure even serum levels. The acetyl-embonates of streptomycin and dihydrostreptomycin are preferred. In the process the streptomycin as water-sol. salt or a complex is reacted in known manner with an acylembonic acid as water-sol. salt or as DMF adduct. Good yields are obtained.