DE1943207

DE1943207

1,224,576. Tetrapeptide. TANABE SEIYAKU CO. Ltd. 20 Aug., 1969 [24 Aug., 1968], No. 41448/69. Heading C2C. R-Gly-Trp-Met-GlyNH 2 where R is an amino protecting group especially an alkylcarbonyl, alkoxycarbonyl, aralkoxycarbonyl or arylsulphenyl group is prepared by amidating the corresponding ester...

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Bibliographische Detailangaben
Hauptverfasser: NIWA, KOUICHI, IKEDA, OHNISHI, TAKANOBU, OSAKA, MIYOSHI, MUNETUGU, NISHINOMIYA, HYOGO, DANNO, TAMOTSU, MORIGUCHI, OSAKA, HIGAKI, KOH, NARA
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Zusammenfassung:1,224,576. Tetrapeptide. TANABE SEIYAKU CO. Ltd. 20 Aug., 1969 [24 Aug., 1968], No. 41448/69. Heading C2C. R-Gly-Trp-Met-GlyNH 2 where R is an amino protecting group especially an alkylcarbonyl, alkoxycarbonyl, aralkoxycarbonyl or arylsulphenyl group is prepared by amidating the corresponding ester in turn prepared by condensing individual amino acids with each other or with smaller peptide units while protecting functional groups not participating in the reaction. The following intermediates are prepared:- BOC - Trp - Met - GlyOMe, H - Trp - Met- GlyOMe, BOC - Gly - Trp - MetOMe and its hydrazide. Pharmaceutical compositions for inhibiting gastric secretions may be in a form suitable for oral or parenteral administration.