Biphenylisopropyloxycarbonylfluoride - for acylation of amino acids

Biphenylisopropyloxycrbonylflouride for acylation of amino acids Title cpd is highly suitable for protection of alpha-amino of amino-acids in the synth. of penicillins. The protecting group is easily removed by dil. CH3CO2H at 0-100 degrees C. Fluoride is obtd. by reacting biphenylisopropanol with c...

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Bibliographische Detailangaben
Hauptverfasser: GUNTER SCHMIDT,DR, ERICH KLAUKE,DR, EUGEN SCHNABEL,DR
Format: Patent
Sprache:eng ; ger
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Zusammenfassung:Biphenylisopropyloxycrbonylflouride for acylation of amino acids Title cpd is highly suitable for protection of alpha-amino of amino-acids in the synth. of penicillins. The protecting group is easily removed by dil. CH3CO2H at 0-100 degrees C. Fluoride is obtd. by reacting biphenylisopropanol with carbonylfluoridechloride or -bromide, pref. at -20 degrees C in a volatile solvent in the presence of an acid-binding agent.