2-benzylamino-5-alkoxy-pyrimidines active - against influenza virus

2-benzylamino-5-alkoxy-pyrimidines active - against influenza virus

Title cpds. are 2-(R2,R3,R4-benzylamino)-5-(1-4C alkoxy)-pyrimidines and their acceptable acid salts (where R2 is H, 1-4C alkyl or alkoxy or halogen, and R3 and R4 are H or 1-4C alkyl), which have better anti-influenza activity than ABOB hydrochloride and amantadine hydrochloride and lower toxicity....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SRINIVAS MURTHY,DR, DIETER RAHTZ,DR, KLAUS GUTSCHE,DR
Format: Patent
Sprache:eng ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Title cpds. are 2-(R2,R3,R4-benzylamino)-5-(1-4C alkoxy)-pyrimidines and their acceptable acid salts (where R2 is H, 1-4C alkyl or alkoxy or halogen, and R3 and R4 are H or 1-4C alkyl), which have better anti-influenza activity than ABOB hydrochloride and amantadine hydrochloride and lower toxicity. Pref. cpds. are 5-methoxy-2-((3,4,5-trimethoxybenzyl)-amino)-pyrimidin, 2-benzylamino-5-methoxypyrimidin, etc.