Verfahren zur Herstellung von Hexose-1,6-bzw,Pentose-1,5-diphosphaten

Prepn. of hexose-1, 6-& pentose-1, 5-diphosphates. As coenzymes. The sugar 5/6-monophosphate is acylated, pref. with Ac2O & opt. in the presence of a catalyst & solvent, volatiles removed in vacuo at 40-80 deg., & the residue heated in vacuo with excess (3-5 moles) of anhyd. ortho &a...

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Hauptverfasser:	HAID,ERICH, NELBOECK-HOCHSTETTER,DR.PHIL.MICHAEL
Format:	Patent
Sprache:	ger
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY DERIVATIVES THEREOF METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SUGARS
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Zusammenfassung:	Prepn. of hexose-1, 6-& pentose-1, 5-diphosphates. As coenzymes. The sugar 5/6-monophosphate is acylated, pref. with Ac2O & opt. in the presence of a catalyst & solvent, volatiles removed in vacuo at 40-80 deg., & the residue heated in vacuo with excess (3-5 moles) of anhyd. ortho &/or pyrophosphoric acid at 50-80 deg. for 1-2 hr. The product is basified, pref. with MeOH-NaOH, to ppt. a mixt. of di- & monophosphates & inorg. salts. These are filtered or centrifuged, dissd. in hot water, the pH adjusted to 9.0 & the soln. cooled to 0 deg. to ppt. Na2HPO4.12H2O; the rest of the phosphate is removed as the Mg-NH4 salt. Starting material is sepd. by taking the filtrate to pH 7.5, boiling & adding Ba++ & filtering hot to recover the pptd. Ba salt of the product.