Verfahren zur fermentativen Herstellung von Tetracyklin

Tetracycline is produced by cultivating a strain of Streptomyces aureofaciens, capable of producing both chlortetracycline and tetracycline, in a liquid nutrient medium containing assimilable carbon and nitrogen sources, inorganic nutrient salts and a chlorination inhibitor which is a natural liquid...

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Bibliographische Detailangaben
Hauptverfasser:	MILOS HEROLD, KAREL CULIK,DR, JOSEF PALKOSKA, JOSEF STEJSKAL,DR, HEJDANEK,SLAVOMIL
Format:	Patent
Sprache:	ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Tetracycline is produced by cultivating a strain of Streptomyces aureofaciens, capable of producing both chlortetracycline and tetracycline, in a liquid nutrient medium containing assimilable carbon and nitrogen sources, inorganic nutrient salts and a chlorination inhibitor which is a natural liquid material containing organic-bound sulphur which is present in a plant of the genus Brassica or garlic. The material may be in the form of mustard or rape seed, unrefined oil or cake. Benzyl thiocyanate may be present to stimulate the production of antibiotic.