Tetrahydro-1,3,5-thiadiazin-2-thione und Verfahren zu ihrer Herstellung

Novel tetrahydro - 1,3,5 - thiadiazine - 2-thiones of the formula wherein R1 is a phenyl-lower-alkyl group (the word "lower" indicating a group of up to 6 carbon atoms), in which the phenyl nucleus may be halo-substituted, A is an alkylene group of 2-6 carbon atoms and is a di-lower alkylamino group or a heterocyclic group containing 5-7 ring members, optionally containing at least one further hetero atom, and their physiologically tolerable acid addition salts, are made by reacting a primary amine of the formula R1NH2 with carbon disulphide and treating the resulting dithiocarbamate with formaldehyde and a salt of a diamine of the formula and, if desired, converting the product into its acid addition salt. Pharmaceutical preparations for external treatment of mycotic and bacterial infections comprise 0.05 to 5.0% by weight of the above thiadiazine compounds in admixture or conjunction with a carrier. The products may also be used orally as anthelmintic agents.