Stabile polymorphe Form von (E)-N,N-Diethyl-2-cyano-3(3,4-dihydroxy-5-nitrophenyl)-Acrylamid und Verfahren zu ihrer Herstellung

Stabile polymorphe Form von (E)-N,N-Diethyl-2-cyano-3(3,4-dihydroxy-5-nitrophenyl)-Acrylamid und Verfahren zu ihrer Herstellung

Stable and crystallographically essentially pure polymorphic form A of (E)-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitro-phenyl)acrylamide may be prepared by crystallizing crude synthesis product from lower aliphatic carboxylic acid such as formic or acetic acid with a catalytic amount of hydrochlori...

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Bibliographische Detailangaben
Hauptverfasser: HAARALA JORMA VEIKKO, HONKANEN ERKKI JUHANI, PIPPURI AINO KYLLIKKI
Format: Patent
Sprache:ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Stable and crystallographically essentially pure polymorphic form A of (E)-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitro-phenyl)acrylamide may be prepared by crystallizing crude synthesis product from lower aliphatic carboxylic acid such as formic or acetic acid with a catalytic amount of hydrochloric or hydrobromic acid added. The product is a potent inhibitor of catechol-O-methyl-transferase enzyme (COMT).