Verfahren zur Herstellung sekundaer-tertiaerer Propargylaethandiole

The invention comprises compounds of the general formula (wherein R1 represents an aliphatic hydrocarbon group and R2 represents an alkyl or aryl group), pharmaceutical preparations containing them, and their preparation by reacting an a -hydroxyketone of the formula with an organometallic compound derived from a propargyl halide and magnesium, aluminium or zinc, followed by decomposition of the metal derivative so formed. The compounds of the invention have sedative, hypnotic and narcotic activity, and may be administered orally or parenterally in the form of pharmaceutical preparations (e.g. powders, granules, syrups, emulsions, suspensions, tablets, coated tablets, pills, capsules and cachets, or preparations contained in ampoules) containing them in association with a carrier or excipient. Specification 966,115 is referred to.