Jodierte neurosonde zum erfassen von monodamin-wiederaufnahme-orten

An iodinated neuroprobe is provided for mapping monoamine reuptake sites. The iodinated neuroprobe is of the formula: wherein R=a CnH2n+1 group where n=0-6, an alkenyl group, a monofluoroalkyl group including nF where n=18 or 19, or a mCnH2n+1 group where n=1-6 and where m=11 or 14 for at least one...

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Hauptverfasser: INNIS, ROBERT, B, NEUMEYER, JOHN, L, MILIUS, RICHARD, A
Format: Patent
Sprache:ger
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Zusammenfassung:An iodinated neuroprobe is provided for mapping monoamine reuptake sites. The iodinated neuroprobe is of the formula: wherein R=a CnH2n+1 group where n=0-6, an alkenyl group, a monofluoroalkyl group including nF where n=18 or 19, or a mCnH2n+1 group where n=1-6 and where m=11 or 14 for at least one mC; R'=a CnH2n+1 group where n=0-6, a p-iodophenylmethyl group, a p-iodophenylethyl group, a phenylmethyl group, or a phenylethyl group; X=an isotope of F, an isotope of Cl, an isotope of Br, an isotope of I, CH3, or Sn(R''1R''2R''3); R''1=a CnH2n+1 group where n=1-6, or an aryl group; R''2=a CnH2n+1 group where n=1-6, or an aryl group; R''3=a CnH2n+1 group where n=1-6, or an aryl group; and Y=H only if X is an isotope of I, or R' is a p-iodophenylmethyl group, or R' is a p-iodophenylethyl group, else Y=an isotope of I. Related analogs are also provided. Additionally, a precursor of a radiolabled neuroprobe and a kit for preparing the iodinated neuroprobe are provided.